It's Time TO CHALLENGE OUR
Understanding of TDT  

Transfusion-dependent beta (β)-thalassemia (TDT)
is the most severe form of beta-thalassemia1 Transfusion-dependent beta (β)-thalassemia (TDT) is the most severe form of beta-thalassemia1

TDT is characterized by reduced or absent production of functional beta-globin, which is essential for forming adult hemoglobin. To survive, patients living with TDT require regular lifelong red blood cell transfusions, but this only temporarily addresses the symptoms of disease.1,2 It’s time to challenge our understanding of TDT and consider its genetic cause. TDT is characterized by reduced or absent production of functional beta-globin, which is essential for forming adult hemoglobin. To survive, patients living with TDT require regular lifelong red blood cell transfusions, but this only temporarily addresses the symptoms of disease.1,2 It’s time to challenge our understanding of TDT and consider its genetic cause.
Explore the Genetics of TDT Explore the
Genetics of TDT
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Patients and caregivers reported high TDT burden due to disease-management.3 Patients and caregivers
reported high TDT burden due
to disease-management.3
See More QoL Impact

Growing up
with TDT

Hear how living with TDT can impact patients and their families.
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man walking

Actor portrayal. Not a real patient.

Take the Beta-Thalassemia
Challenge

The ​​2021 Guidelines for the Management of Transfusion Dependent Thalassaemia, published by the Thalassaemia International Federation (TIF), recommend that:

Actor portrayal. Not a real patient.